SIGNIFOR LAR (pasireotide) for injectable suspension Signifor

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1 injection every 4 weeks SIGNIFOR LAR ADMINSTRATION


SIGNIFOR LAR is an intramuscular injection in the left or right gluteus muscle and is administered by a trained healthcare professional every 4 weeks (28 days)

What to test prior to initiation

  • Fasting plasma glucose (FPG) and HbA1c
  • Liver function
  • Electrocardiogram (ECG), serum potassium and serum magnesium levels
Recommended initial dose and maximum dose product images Recommended initial dose and maximum dose product images


  • FPG weekly for the first 3 months and the first 4-6 weeks after dose increases and thereafter as clinically appropriate
  • Liver function after the first 2-3 weeks, then monthly for 3 months and thereafter as clinically indicated
  • ECG after 3 weeks (in patients at risk)

Start dosing at 20 mg for patients with moderately impaired hepatic function with a maximum dose of 40 mg every 4 weeks and avoid use in patients with severe hepatic impairment (Child-Pugh C)

Steps for starting treatment Steps for starting treatment

See Instructions for Preperation and Administration


What to test periodically with SIGNIFOR LAR

  • Hypokalemia and hypomagnesemia
  • Pituitary hormone levels
  • Cholelithiasis and cholelithiasis complications
  • HbA1c

Advise your patients how and when to monitor blood glucose levels as necessary

Indications and Usage

SIGNIFOR LAR (pasireotide) is a somatostatin analog indicated for the treatment of:

Important Safety Information

Warnings and Precautions

Indications and Usage

SIGNIFOR LAR (pasireotide) is a somatostatin analog indicated for the treatment of:

Important Safety Information

Warnings and Precautions

Adverse Reactions

Drug Interactions

Females and Males of Reproductive Potential

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