Signifor LAR Signifor

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Target the source

SIGNIFOR LAR is a prescription medicine used to treat people with acromegaly for whom surgery has not worked well enough or who cannot have surgery.

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  • SIGNIFOR® LAR (pasireotide) is similar to a hormone your body makes, called somatostatin
  • Like somatostatin, SIGNIFOR LAR reduces the amount of growth hormone your body makes
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  • SIGNIFOR LAR is a long-acting treatment. It is given as a monthly injection by a trained healthcare professional

Acromegaly at a glance

Acromegaly is caused by a tumor in your pituitary gland, which is located in the brain. Your doctor may or may not remove the tumor through surgery.

  • In people with acromegaly, the tumor cells still in your pituitary gland cause the gland to make too much growth hormone
  • Too much growth hormone causes your body to produce too much insulin-like growth factor 1 (IGF-1)
  • This overproduction of hormones causes the symptoms of acromegaly

SIGNIFOR LAR works in the pituitary gland to reduce the amount of growth hormone and IGF-1 to help restore hormonal balance and normal growth.

Piuitary gland diagram


by a trained healthcare provider


What to expect on treatment

As with any medication, it is important to familiarize yourself with the benefits and risks so you know what to expect from your treatment and can work closely with your doctor to address any concerns.

Here is some important information for you to know about. Treatment with SIGNIFOR LAR may lead to:

High blood sugar, also known as hyperglycemia, which may cause excessive thirst, high urine output, increased appetite with weight loss, or tiredness

Slow heart rate, also known as bradycardia, or electrical system problem (QT prolongation), both of which may cause weakness, dizziness or fainting

Elevation in liver enzymes, which your doctor may want to test

Gallstones, also known as cholelithiasis, which may require an ultrasound

Low cortisol, also known as hypocortisolism, which may cause weakness, fatigue, loss of appetite, nausea, vomiting, low blood pressure, a low level of sodium in the blood or low blood sugar

Indications and Usage

SIGNIFOR LAR (pasireotide) is used to help treat:

Important Safety Information

Indications and Usage

SIGNIFOR LAR (pasireotide) is used to help treat:

Important Safety Information