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Tired of asking
What now?
It’s time to ask about SIGNIFOR LAR, an acromegaly treatment that works differently
See how SIGNIFOR LAR worksSIGNIFOR LAR is a prescription medicine used to treat adults with acromegaly for whom surgery has not worked well enough or who cannot have surgery.
- SIGNIFOR® LAR (pasireotide) is similar to a hormone your body makes, called somatostatin
- Like somatostatin, SIGNIFOR LAR reduces the amount of growth hormone your body makes
- SIGNIFOR LAR is a long-acting–release treatment. This means that it continues to work in your body in the weeks after it is injected. It is given as a monthly injection by a trained healthcare provider
Acromegaly at a glance
Acromegaly is usually caused by a noncancerous pituitary tumor. The pituitary gland is a small, pea-sized gland at the base of your brain.
- This tumor causes too much growth hormone (GH) to be made.
- Too much GH causes your body to produce too much insulin-like growth factor 1 (IGF-1), which supports growth of bones and tissues
- This overproduction of hormones over a long period of time causes the symptoms of acromegaly
SIGNIFOR LAR works by reducing the amount of GH and IGF-1 your body makes to help restore hormonal balance.
Dosing
SIGNIFOR LAR:
1 INJECTION EVERY 4 WEEKS (28 DAYS)
by a trained healthcare provider
What should I know about SIGNIFOR LAR?
As with any medicine, it is important to familiarize yourself with the benefits and risks so you know what to expect from your treatment and can work closely with your healthcare provider to address any concerns.
SIGNIFOR LAR may cause serious side effects, including
- High blood sugara (also known as hyperglycemia), diabetesa, or increased ketones in your urine or blood (ketoacidosis)
- Slow heart rate (also known as bradycardia)
- Changes in the electrical system of your heart (also known as QT interval prolongation)
- Higher than normal liver function tests
- Gallstonesa (also known as cholelithiasis) and complications that can happen when you have gallstones
- Low levels of pituitary hormones (also known as pituitary insufficiency)
aThese are serious but common side effects of SIGNIFOR LAR.
More information about side effects can be found in the Patient Information section of the full Prescribing Information.
Read more about side effects.
The most common side effects of SIGNIFOR LAR include
- Diarrhea
- Headache
- Stomach-area pain
- Hair loss
- Stuffy nose and sore throat
- Low blood sugar
- Limb swelling
- Loss of appetite
- Nausea
- Increase in the level of an enzyme in your blood called creatine phosphokinase (CPK)
- Tiredness
- Stomach bloating
- High blood pressure
- Back pain
Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of SIGNIFOR LAR. For more information about side effects, ask your healthcare provider or pharmacist or refer to the Patient Information section of the full Prescribing Information.
Please report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. You may also contact Recordati Rare Diseases Inc. at 1-888-575-8344 to report side effects.