Before you receive SIGNIFOR LAR, tell your healthcare provider about all of your medical conditions, including if you:
- Have high blood sugar (hyperglycemia)
- Have diabetes
- Have or have had heart problems, including an abnormal heart rate or rhythm or problems with the electrical system of your heart (QT prolongation)
- Have a low level of potassium or magnesium in your blood
- Have liver problems
- Have gallstones (cholelithiasis)
- Are pregnant or plan to become pregnant. It is not known if SIGNIFOR LAR will harm your unborn baby
- Are breastfeeding or plan to breastfeed. It is not known if SIGNIFOR LAR passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you take SIGNIFOR LAR
Treatment with SIGNIFOR LAR may result in improved fertility and the possibility of unplanned pregnancy in women who have Cushing’s disease and have not gone through menopause. Talk to your healthcare provider about birth control methods that may be right for you during treatment with SIGNIFOR LAR.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
SIGNIFOR LAR and other medicines may affect each other, causing side effects. SIGNIFOR LAR may affect the way other medicines work, and other medicines may affect how SIGNIFOR LAR works. Your healthcare provider may need to change your dose of SIGNIFOR LAR or your other medicines. Especially tell your healthcare provider if you take:
- Medicines to control your heart beat (antiarrhythmics)
- Medicines to control your blood pressure (such as beta blockers or calcium channel blockers)
- Medicines to control the potassium and magnesium (electrolytes) levels in your body
- Medicines that may affect the way the electrical system of your heart works (QT prolongation)
Ask your healthcare provider for a list of these medicines if you are not sure.
Know the medicines you take, and keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.