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For patient support, please call: 1-888-855-7273

Find valuable resources to help you during your treatment

Cushing’s disease overview brochure

Cushing’s disease overview brochure

This brochure provides education for people who want to know more about Cushing’s disease.

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FAQs

FAQs

Find answers to frequently asked questions about SIGNIFOR® LAR (pasireotide).

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SIGNIFOR LAR Patient Brochure

SIGNIFOR® LAR patient brochure

Information about starting treatment with SIGNIFOR® LAR.

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Symptom and self-monitoring diary

Symptom and self-monitoring diary

A tool to help you track your symptoms and treatment.

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Contact a nurse specialist

Nursing support

A clinical nurse specialist is available to answer any questions you may have about your treatment.

You can contact a nurse specialist at 1-888-855-7273.

What is SIGNIFOR LAR?

SIGNIFOR LAR is a prescription medicine used to treat people with Cushing’s disease for whom surgery has not worked well enough or who cannot have surgery. It is not known if SIGNIFOR LAR is safe and effective for use in children.


IMPORTANT SAFETY INFORMATION

Before starting SIGNIFOR LAR, tell your healthcare provider (HCP) about all your medical conditions, including if you:

INDICATION(S) AND IMPORTANT SAFETY INFORMATION


What is SIGNIFOR LAR?


SIGNIFOR LAR is a prescription medicine used to treat people with Cushing's disease for whom surgery has not worked well enough or who cannot have surgery.


It is not known if SIGNIFOR LAR is safe and effective for use in children.


IMPORTANT SAFETY INFORMATION


Before starting SIGNIFOR LAR, tell your healthcare provider (HCP) about all your medical conditions, including if you:


Females and Males of Reproductive Potential: Treatment with SIGNIFOR LAR may result in improved fertility and the possibility of unplanned pregnancy in females who have acromegaly or Cushing’s disease and have not gone through menopause. Talk to your healthcare provider about birth control methods that may be right for you during treatment.


Tell your healthcare provider about all the medicines you take, including any prescription and over-the-counter medicines, vitamins, or herbal supplements.


SIGNIFOR LAR and other medicines may affect each other, causing side effects. Your healthcare provider may need to change your dose of SIGNIFOR LAR or your other medicines. Especially tell your healthcare provider if you take medicines to control your heart beat (antiarrhythmics), your blood pressure (beta-blockers or calcium channel blockers), potassium and magnesium (electrolytes) levels in your body, medicines that may affect the way the electrical system of your heart works (QT prolongation), cyclosporine, and bromocriptine.


What are the possible side effects of SIGNIFOR LAR?


SIGNIFOR LAR may cause serious side effects including:


The most common side effects of SIGNIFOR LAR include diarrhea, headache, stomach-area pain, hair loss, stuffy nose and sore throat, low blood sugar, limb swelling, loss of appetite, nausea, increase in level of the creatine phosphokinase (CPK) enzyme in your blood, tiredness, stomach bloating, high blood pressure, back pain.


These are not all the possible side effects of SIGNIFOR LAR. Call your HCP for medical advice about side effects. You are encouraged to report side effects of prescription drugs to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.


SIGNIFOR LAR® (pasireotide) for injectable suspension, for intramuscular use, is available as 10 mg, 20 mg, 30 mg, 40 mg, and 60 mg powder in a vial to be reconstituted with the provided 2 mL diluent.


Please see full Prescribing Information and Patient Information.

Laura's story
Laura
MY JOURNEY TO DIAGNOSIS

I've been living with acromegaly for 7 years. Things like elevated prolactin, extremity growth, and intense headaches were the first signs. After finding an endocrinologist, I was finally diagnosed with acromegaly.

OVERCOMING CHALLENGES

Acromegaly has worn on me and my overall health. I tried many treatments before. SIGNIFOR® LAR (pasireotide) helps lower my IGF-1 levels. That's a big deal for me.

MY MESSAGE TO OTHERS

“It's not about the challenges you face, but the strength you find within yourself. After all, you are RARE—resilient, adaptable, remarkable, enduring.”

Laura found what works for her. Learn more about SIGNIFOR LAR and talk to a doctor to see if it may be right for you.

Have You Just Been Prescribed SIGNIFOR® LAR (pasireotide)?
Home Injection Program Available

Good news! A registered nurse can come to your home to administer your treatment— at no cost to you or your insurance provider. This program is designed to make your treatment journey more convenient by bringing this professional care directly to you.

Already Enrolled?

Your nurse will reach out soon to schedule your next appointment.

Not Signed Up Yet?

Call us. The R.A.R.E.® Patient Support Program is here to help.

Call 1-888-855-RARE (7273)

Monday-Friday, 8:00 AM-8:00 PM ET

A pharmacist is always available.