Resources | SIGNIFOR® LAR (pasireotide)

Find valuable resources to help you during your treatment

Cushing’s disease overview brochure

This brochure provides education for people who want to know more about Cushing’s disease.

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FAQs

Find answers to frequently asked questions about SIGNIFOR^® LAR (pasireotide).

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SIGNIFOR^® LAR patient brochure

Information about starting treatment with SIGNIFOR^® LAR.

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Symptom and self-monitoring diary

A tool to help you track your symptoms and treatment.

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Nursing support

A clinical nurse specialist is available to answer any questions you may have about your treatment.

You can contact a nurse specialist at 1-888-855-7273.

Helpful links

The following websites can provide you with more information about Cushing’s disease.

The Endocrine Society

Hormone Health Network

National Adrenal Diseases Foundation

National Institute of Diabetes and Digestive and Kidney Diseases

National Institutes for Health

National Organization for Rare Disorders

Pituitary Network Association

LEARN ABOUT R.A.R.E. PATIENT SUPPORT Program

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SIGNIFOR LAR

Important Safety Information

High blood sugar (hyperglycemia), diabetes, and increased ketones in your urine or blood (ketoacidosis): SIGNIFOR LAR can cause serious side effects such as high blood sugar (hyperglycemia), diabetes, and ketoacidosis. Your healthcare provider should check your blood sugar level before you start receiving SIGNIFOR LAR and while you receive it. Tell your healthcare provider right away if you have any of these symptoms: feel very thirsty, urinate more than usual, nausea, vomiting, abdominal pain, increased appetite with weight loss, tiredness, fruity scented breath, trouble breathing, and/or confusion. If you get hyperglycemia, your healthcare provider may give you medicine to lower your blood sugar and/or change your dose of SIGNIFOR LAR or advise you to stop receiving it.

Important Safety Information

Slow heart rate (bradycardia) and changes in the electrical system of your heart (QT Prolongation): SIGNIFOR LAR (pasireotide) can cause your heart to beat slower, which can cause you to feel weak, dizzy, or even faint. People who have, or have had, heart problems, are at greater risk for bradycardia. Abnormal heart beats, weakness, dizziness, and fainting spells may occur due to problems with the electrical system of the heart and can be serious. Call your doctor right away if you experience such spells.

Liver Test Elevations: SIGNIFOR LAR (pasireotide) can cause higher than normal liver function tests. Your healthcare provider should do blood tests to check your liver while you receive SIGNIFOR LAR (pasireotide).

Gallstones (cholelithiasis) and complications that can happen if you have gallstones: Gallstones are a serious but common side effect of SIGNIFOR LAR (pasireotide). Your healthcare provider should do a test (ultrasound) to check your gall bladder before and during your treatment.

Low levels of pituitary hormones (pituitary insufficiency): SIGNIFOR LAR (pasireotide) reduces the pituitary hormones in your body. Your healthcare provider should do a blood test to check your pituitary hormone levels before you start receiving SIGNIFOR LAR (pasireotide) and while you receive it.

Most common side effects of SIGNIFOR LAR (pasireotide) include: diarrhea; headache; stomach-area pain; hair loss; stuffy nose and sore throat; low blood sugar; limb swelling; loss of appetite; nausea; increase in the level of the enzyme in your blood called creatine phosphokinase (CPK); tiredness; stomach bloating, high blood pressure; back pain. These are not all the possible side effects of SIGNIFOR LAR (pasireotide). For more information, ask your healthcare provider.

To report SUSPECTED SIDE EFFECTS, contact Recordati Rare Diseases Inc. at 1-888-575-8344, or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Before Taking SIGNIFOR LAR (pasireotide) patients should tell their doctor about all of their medications. SIGNIFOR LAR (pasireotide) may affect the way other medicines work, and other medicines may affect how SIGNIFOR LAR (pasireotide) works. Especially tell your healthcare provider if you take medicines to control your heart beat (antiarrhythmics), medicines to control your blood pressure (beta-blockers or calcium channel blockers), medicines to control the potassium and magnesium (electrolytes) levels in your body, medicines that may affect the way the electrical system of your heart works (QT prolongation), cyclosporine, and bromocriptine.

Use in Specific Populations:

Females and Males of Reproductive Potential: Treatment with SIGNIFOR LAR (pasireotide) may result in improved fertility and the possibility of unplanned pregnancy in females who have not gone through menopause. Talk to your healthcare provider about birth control methods that may be right for you during treatment.
It is not known if SIGNIFOR LAR (pasireotide) is safe and effective for use in children.

Signifor

Find valuable resources to help you during your treatment

Cushing’s disease overview brochure

FAQs

SIGNIFOR^® LAR patient brochure

Symptom and self-monitoring diary

Nursing support

Helpful links

Indications and Usage

Important Safety Information

Indications and Usage

Important Safety Information

Find valuable resources to help you during your treatment

Cushing’s disease overview brochure

FAQs

SIGNIFOR® LAR patient brochure

Symptom and self-monitoring diary

Nursing support

Helpful links

Indications and Usage

Important Safety Information

Indications and Usage

Important Safety Information

Are you a Healthcare Professional?

SIGNIFOR^® LAR patient brochure